CSE 549 - Computational Biology Tentative Lecture Schedule - Fall 2011 Tuesday-Thursday 9:50-11:10PM -- SB Union 236 date subject lecture topic reading deadline ---- ------- ------------- ------- -------- 8/30 Preliminaries Biology for Computer Scientists 57-79 9/1 " Computer Science for Biologists 1-54 9/6* " Genbank and Bio-perl tools web-notes 9/8* Systems Biology (David Green) 9/13 Assembly Data structures for sequences 318-324 9/15 " Shortest common superstring 247-265 9/20 " Phrap, Drosophila assembly 275-287 9/22 Projects Out 9/27 Homology search Exact string matching 311-318 9/29 Rosh Hashanah (no class) 10/4 " Pairwise global alignment 147-177 10/6 " Pairwise local alignment 177-184 10/11 " BLAST, FASTA, GCG 324-337 10/13 MIDTERM EXAM 10/18 Gene prediction Statistical/homological approaches 193-211 10/20 " Hidden Markov Models 387-397 10/25 " Genmark, Grail 397-407 Proposal in 10/27 Array analysis Affymetrics/Microarrays 339-343 11/1* " Sequencing by Hybridization 265-275 11/3 " Clustering and time series analysis 343-354 11/8 " Microarray analysis software web-notes 11/10 " Tour of DNA Microarray Facility Progress in 11/15 Proteins Protein motifs, Swiss Prot, PDB 91-116 11/17 " De novo and threading approaches web-note 11/22 Synthetic Biology (!) 11/24 Thanksgiving (class cancelled) 11/29 Phylogenies Distance metrics 354-368 12/1 " parsimony methods 368-384 12/6 " reversal sorting 125-142 12/8 " student presentations / review 1-417 Project in 12/14 Final Exam (11:15AM-1:45PM) (*) Possible substitute lecturer (+) Outside of normal class time (!) New lecture