·
www.gcg.com
·
SeqLab
environment which is part of the Wisconsin Package
·
Over
130 programs contained within it – It must be purchased
·
Supports
and distributes 5 databases
§
2
nucleic acid
B
Genbank
B
EMBL
(abridged version)
B
combined
GenEMBL plus
§ 3 protein
B PIR – Protein Information
Resource
B SWISS-PROT
B SP-TrEMBL
B combined SWISS-PROT plus
What GCG can do for you
6 kinds of Sequence analysis problems can be solved with SeqLab by GCG
1. Finding related entries in database through
reference searching and aligning them.
2. Finding open reading frames (ORFs) in 2
mRNAs, Translating them, and aligning the RNAs and proteins.
3. Searching a database with a query sequence,
aligning the found entries and the query sequence to SeqLab editor and select
FASTA program.
4. Assembling overlapping sequence fragments to
Generate a contiguous sequence, finding and translating the coding regions of
that sequence, and searching a database for similar sequences. (ex BLAST)
5. Aligning related protein sequences,
calculating a consensus sequence for the alignment, identifying a novel pattern
in the sequences and searching a database for sequences that contain that
pattern, or searching the alignment consensus for known protein patterns.
6. Using profiles for similarity searches and
aligning related sequences.
Conclusion
GCG has just about everything you need to decide if two genes are
homologous, BUT you have to buy it!