A: In general, the procedures are:

1. get a copy of the article(s) given in the reference lines;
2. the sequence is aligned, using FastA or Blast, against all existing SWISS-PROT and TrEMBL entries
3. read the article(s), assess the information.

In practice, there are several cases to consider:

I.   Sequence published with biochemical characterization

II.  Sequence published without biochemical study

III. Protein sequence from translation of genome sequencing data

     1. identical to an existing sequence in SWISS-PROT from the same organism,
	  modify the references;
     2. identical to an existing sequence in SWISS-PROT from a different organism which 
	  may or may not be related, modify the reference and organism name lines;
     3. strong similarity (i.e. many residues are conserved residues), over the
          entire sequence, to an existing entry (from a related or different
          organism), special consideration necessary-- see example;
     4. strong similarity only at regions in the sequence (from same, related
          or different organism), special consideration necessary-- see example;
     5. some similarity to one or more existing entries,
	  special consideration necessary-- see example;
     6. no similarity to any existing entries, see example